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Am J Obstet Gynecol. 1995 Apr;172(4 Pt 1):1229-35.

Combining humerus and femur length for improved ultrasonographic identification of pregnancies at increased risk for trisomy 21.

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1
Department of Obstetrics and Gynecology, Hutzel Hospital-Wayne State University, Detroit, Michigan, USA.

Abstract

OBJECTIVE:

Our purpose was to evaluate the value of the combination of femur and humerus length measurements in ultrasonographic screening for trisomy 21.

STUDY DESIGN:

Direct necropsy measurements were analyzed on 703 midgestational fetuses (641 normal, 62 with trisomy 21). The (leg+arm length)/foot length ratio was found to be significantly shortened for fetuses with trisomy 21. On the basis of necropsy data 576 midgestational pregnancies were evaluated ultrasonographically for (femur+humerus length)/foot length ratio to identify fetuses at increased risk for trisomy 21.

RESULTS:

An ultrasonographic (femur+humerus length)/foot length ratio < or = 1.75 gave a 15.3 odds ratio risk for trisomy 21 in our high-risk population and correctly identified 53% of fetuses with trisomy 21, with a false-positive rate of 7%. In addition, the use of this ratio eliminates the need for gestational age-corrected nomograms and complicated calculations in ultrasonographic screening.

CONCLUSION:

The (femur+humerus length)/foot length ratio may be an additional effective ultrasonographic marker for identification of fetuses at increased risk for trisomy 21.

PMID:
7726261
[Indexed for MEDLINE]
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