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Stat Med. 1995 Feb 15;14(3):231-46.

Adaptive assignment versus balanced randomization in clinical trials: a decision analysis.

Author information

1
Duke University, Institute of Statistics and Decision Sciences, Durham, NC 27708, USA.

Abstract

We compare balanced randomization with four adaptive treatment allocation procedures in a clinical trial involving two treatments. The objective is to treat as many patients in and out of the trial as effectively as possible. Randomization is a satisfactory solution to the decision problem when the disease in question is at least moderately common. Adaptive procedures are more difficult to use, but might play a role in clinical research when a substantial proportion of all patients with the disease are included in the trial.

PMID:
7724909
[Indexed for MEDLINE]

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