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Ophthalmology. 1995 Apr;102(4):599-606.

The effect of phenylephrine on Müller muscle. A blepharogram study of eyelid motion.

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1
Dean A. McGee Eye Institute, Oklahoma City, OK 73104, USA.

Abstract

PURPOSE:

The blepharogram technique is used to study the effect of a drug on blinking. The authors show that ocular instillation of phenylephrine, a stimulant of Müller muscle of the eyelid, accelerates the up phase of the blink.

METHODS:

Motion of a tiny search coil glued to the eyelid moving in a weak magnetic field modifies an induced alternating current which is amplified and used to display the position of the upper eyelid in degrees on the ordinate of a graph with time in milliseconds on the abscissa. The graph is called a blepharogram. Blepharogram studies and individual blink analysis show the effect of phenylephrine on eyelid motion (blinking).

RESULTS:

Instillation of phenylephrine accelerated the up phase of the blink in all ten experimental subjects. In 65% of subjects, phenylephrine also produced or increased newly described N and M blepharogram patterns.

CONCLUSION:

This is the first instrumental detection of the effect of a pharmacologic agent on eyelid motion. The blepharogram technique provides insight into eyelid physiology and can be used to study any neuromuscular condition that affects eyelid motion.

PMID:
7724177
[Indexed for MEDLINE]
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