Send to

Choose Destination
See comment in PubMed Commons below
Neurosci Res. 1994 Dec;21(2):119-24.

Telencephalin: a neuronal area code molecule?

Author information

  • 1Department of Neuroscience, Osaka Bioscience Institute, Japan.


Cell adhesion molecules (CAMs) with expression restricted to specific developmental and structural units of the brain and/or selective neuronal types would play critical roles in the formation of functional neuronal networks. In this article, we summarize recent progress in knowledge on a brain segment-specific CAM, telencephalin (TLN). TLN has the following characteristic properties. (1) TLN is a neuronal glycoprotein whose expression is restricted within telencephalon, the most rostal segment of the brain. (2) TLN is localized to the soma-dendritic membrane of subsets of telencephalic neurons, but not to the axonal membrane. (3) Abrupt appearance of TLN around birth parallels the timing of dendritic development and synapse formation in the telencephalon. (4) TLN belongs to the immunoglobulin superfamily and its structure is most closely related to intercellular adhesion molecules (ICAMs)-1 and -3. These findings suggest that TLN is the first example of dendrite-associated cell adhesion molecules (DenCAMs) and that TLN may be involved in the brain segmental organization, cell-cell interactions during dendritic development, and maintenance of functional neuronal networks. We discuss the possibility that TLN is an area code-like address signal that is displayed selectively by telencephalic neurons and is decoded by specific subsets of growing axons to make proper synaptic connections.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center