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Lancet. 1995 May 6;345(8958):1148-50.

Emergence of fluoroquinolone-resistant tuberculosis in New York City.

Author information

1
New York City Department of Health, New York, USA.

Abstract

22 patients infected with fluoroquinolone-resistant Mycobacterium tuberculosis in New York City were identified between January, 1991, and November, 1993. In 16 patients resistance arose as a result of inadequate or inappropriate treatment. 6 patients had primary infection with fluoroquinolone-resistant organisms; 5 acquired the organisms nosocomially. Seven distinct patterns of restriction-fragment length polymorphism were identified in isolates from 21 patients. Fluoroquinolones should be restricted to patients with multidrug-resistant disease or intolerance to other antituberculosis drugs. All patients with multidrug-resistant tuberculosis should be on directly observed therapy.

PMID:
7723548
DOI:
10.1016/s0140-6736(95)90980-x
[Indexed for MEDLINE]

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