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FEBS Lett. 1995 Apr 3;362(2):243-6.

Liposome destabilization induced by the HIV-1 fusion peptide effect of a single amino acid substitution.

Author information

1
Department of Biochemistry and Molecular Biology, University of the Basque Country, Bilbao, Spain.

Abstract

The 23-residue synthetic peptide representing the N-terminus of HIV-1 gp41 is known to induce either leakage or fusion of lipid vesicles depending on the experimental conditions. In this paper we report that a polar amino acid substitution V-->E at position 2, known to block gp41 activity in vivo, makes the peptide unable to destabilize and/or fuse membranes. Moreover this variant, unlike the parent peptide, is never found in the membrane-associated beta conformation.

PMID:
7720880
DOI:
10.1016/0014-5793(95)00257-a
[Indexed for MEDLINE]
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