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Distribution of cisplatin in perilymph and cerebrospinal fluid after intravenous administration in the guinea pig.

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  • 1Department of Otolaryngology, Karolinska Hospital, Stockholm, Sweden.

Abstract

The concentration of free cisplatin was followed in plasma, scala tympani perilymph and cerebrospinal fluid (CSF) after an intravenous injection (12.5 mg/kg) in guinea pigs. Liquid chromatography with postcolumn derivatization was used for quantitative determination of the drug. The distribution of cisplatin to CSF was fast; at 10 min after drug administration the concentration was 7 micrograms/ml and the CSF:plasma ratio was 0.37. Cisplatin seems to distribute more slowly to the perilymphatic compartment. The highest concentration measured was 4 micrograms/ml at 20 min after the injection, and the perilymph:plasma ratio was 0.40 at that time. The concentration-time curves generated for cisplatin in perilymph and CSF were similar. No accumulation in the perilymphatic compartment or CSF was observed.

PMID:
7720182
DOI:
10.1007/BF00685738
[PubMed - indexed for MEDLINE]
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