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Arthritis Rheum. 1995 Apr;38(4):547-50.

HLA-DR8 and acute anterior uveitis in ankylosing spondylitis.

Author information

1
University of Tokyo School of Medicine, Japan.

Abstract

OBJECTIVE:

To identify possible factors in the development of acute anterior uveitis (AUU) in patients with ankylosing spondylitis (AS).

METHODS:

We investigated HLA antigens serologically, and HLA-DRB1*08 alleles by polymerase chain reaction-restriction fragment length polymorphism, in 42 Japanese AS patients with and without AAU.

RESULTS:

Thirty-six of the AS patients (85.7%) had HLA-B27. Thirteen (65%) of the 20 patients with AAU had HLA-DR8, whereas only 1 (4.5%) of the 22 patients without AAU had DR8. The difference was statistically significant (Pcorr < 0.001).

CONCLUSION:

Our data suggest that HLA-B27 is strongly associated with AS in Japanese patients and that HLA-DR8 is important for the development of AAU in Japanese patients with AS.

PMID:
7718009
[Indexed for MEDLINE]

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