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Science. 1995 Apr 21;268(5209):429-31.

Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein.

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Division of Cell Growth and Regulation, Dana-Farber Cancer Institute, Boston, MA, USA.


Infection by human immunodeficiency virus-type 1 (HIV-1) is typified by the progressive depletion of CD4 T lymphocytes and deterioration of immune function in most patients. A central unresolved issue in acquired immunodeficiency syndrome (AIDS) pathogenesis is the mechanism underlying this T cell depletion. HIV-1 Tat protein was shown to induce cell death by apoptosis in a T cell line and in cultured peripheral blood mononuclear cells from uninfected donors. This Tat-induced apoptosis was inhibitable by growth factors and was associated with enhanced activation of cyclin-dependent kinases.

[Indexed for MEDLINE]

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