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Neurosci Lett. 1994 Dec 5;182(2):271-4.

Production of interleukin-3 by murine central nervous system neurons.

Author information

1
Department of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Tokyo, Japan.

Abstract

We examined expression and production of interleukin-3 (IL-3) mRNA and IL-3 protein in mouse primary cultured neurons and glia by the reverse transcription and polymerase chain reaction and a bioassay using an IL-3-dependent cell line. IL-3 mRNA was demonstrated mainly in hippocampal neurons but not in glia, while a small but definite production of bioactive IL-3 was detected in septal and hippocampal neuronal cultures. Thus, endogenous IL-3 might be produced by certain neurons in situ.

PMID:
7715825
DOI:
10.1016/0304-3940(94)90814-1
[Indexed for MEDLINE]

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