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Neurosci Lett. 1994 Dec 5;182(2):151-4.

Immunohistochemical evidence for amyloid beta in rat soleus muscle in chloroquine-induced myopathy.

Author information

1
Department of Microbiology, Sapporo Medical University, School of Medicine, Japan.

Abstract

Deposition of amyloid beta (A beta) is one of the pathological hallmarks of brains affected with Alzheimer's disease (AD). The accumulation of A beta have been observed in human myopathies with rimmed vacuoles (RVs) which might involve lysosomal function. Chloroquine, a potent lysosomotropic agent, induces muscle pathology in experimental animals similar to myopathy with RV. In this study, we demonstrate, for the first time, immunohistochemical evidence that A beta and cathepsin D, a lysosomal enzyme, accumulate in vacuolated rat soleus muscle due to chloroquine-induced myopathy. These data indicate that lysosomes are important in the metabolism of amyloid precursor protein to generate A beta. This experimental system seems to be useful not only to study basic mechanisms underlying RV myopathy but also to understand processing of amyloid precursor protein to A beta in AD.

PMID:
7715800
DOI:
10.1016/0304-3940(94)90785-4
[Indexed for MEDLINE]

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