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J Urol. 1995 May;153(5):1641-3.

Delayed hypersensitivity reaction after infusion of nonionic intravenous contrast material for an excretory urogram: a case report and review of the literature.

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  • 1Department of Urology, Case Western Reserve University, Cleveland, Ohio, USA.


Delayed adverse reactions to ionic and nonionic intravenous contrast media have been reported previously. We report a case in which delayed hypersensitivity to iohexol, a nonionic intravenous contrast agent commonly used in excretory urography, resulted in a bi-phasic allergic response. This reaction consisted of a mild post-infusion episode of urticaria, which preceded and was clinically distinct from a moderately severe dermatological eruption. The episode of urticaria was self-limited. The dermatological reaction was treated successfully with antihistamine therapy.

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