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Genomics. 1994 Dec;24(3):597-600.

Mapping of the pulmonary surfactant SP5 (SFTP2) locus to 8p21 and characterization of a microsatellite repeat marker that shows frequent loss of heterozygosity in human carcinomas.

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1
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.

Abstract

We have identified 4 cosmids at the SFTP2 locus by cDNA hybridization. SFTP2 was mapped using a polymorphic CA repeat and localized to 8p21 by FISH. Allele loss in carcinomas was detected using this PCR marker. Among 11 lung and colon tumors, 6 of 9 informative cases exhibited allelic loss.

PMID:
7713515
DOI:
10.1006/geno.1994.1673
[Indexed for MEDLINE]
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