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Curr Opin Struct Biol. 1994 Dec;4(6):912-8.

The regulation of catalysis in ATP synthase.

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Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.


ATP synthase is regulated so as to prevent futile hydrolysis of ATP when the transmembrane proton electrochemical gradient, delta mu H+, falls. Mitochondria and chloroplasts have different mechanisms for inhibition of ATP synthase: by binding an inhibitor protein, and by stabilization of the ADP-inhibited state by making an intramolecular disulphide bond, respectively. The recently determined structure of bovine F1-ATPase is locked in a conformation that probably represents the ADP-inhibited state of the enzyme.

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