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Curr Opin Struct Biol. 1994 Dec;4(6):893-901.

Domain movements in protein kinases.

Author information

1
Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla 92093-0654.

Abstract

Structural studies of the catalytic subunit of the cAMP-dependent protein kinase, both by crystallographic methods and in solution, reveal two conformations. Crystal structures of several other protein kinases have also been solved in the past year. With this combined information we can begin to define mobile domains and subdomains within the conserved catalytic core.

PMID:
7712293
DOI:
10.1016/0959-440x(94)90272-0
[Indexed for MEDLINE]

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