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Biochim Biophys Acta. 1995 Apr 4;1261(2):301-3.

The putative Drosophila NMDARA1 gene is located on the second chromosome and is ubiquitously expressed in embryogenesis.

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Department of Genetics, Case Western Reserve University, Cleveland, OH 44106-4955, USA.


We describe the cDNA sequence of a Drosophila gene located at 49D on the second chromosome. The predicted protein sequence has extensive homology (46% identity, 76% similarity) along its entire length to the central portion of the mammalian brain-specific NMDARA1 glutamate binding protein. While RNA expression studies of the Drosophila protein shown that it is ubiquitously expressed throughout embryogenesis, there appears to be a selective accumulation of transcript in the precursor for the larval brain. The similarity in both expression and sequence suggests that the two proteins may share a conserved function.

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