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Arch Surg. 1995 Apr;130(4):420-2.

Efficacy of a fibrin hemostatic bandage in controlling hemorrhage from experimental arterial injuries.

Author information

1
Letterman Army Institute of Research, Presidio of San Francisco, Calif, USA.

Abstract

OBJECTIVE:

To determine if a pressure dressing containing fibrinogen and thrombin could provide more effective control of arterial hemorrhage than a pressure dressing alone in an animal model of arterial injury.

DESIGN:

Randomized acute (nonsurvival) experiment in swine.

SETTING:

Federal biomedical research institute.

ANIMALS:

Six anesthetized Yorkshire swine.

INTERVENTIONS:

Uncontrolled arterial hemorrhage was induced in anesthetized swine by creating femoral artery lacerations. Hemorrhage was controlled by a gauze bandage containing fibrinogen and thrombin, applied with 1 minute of 3.5-kg pressure. The dressings were left in place for 1 hour after the pressure was removed. The contralateral limbs received identical treatment with plain gauze dressings.

MAIN OUTCOME MEASURES:

Total blood loss, mean arterial pressure, and mortality were measured after 1 hour.

RESULTS:

After 1 hour, blood loss in the fibrin bandage group was 123 +/- 48 mL, compared with 734 +/- 134 mL in the control group (P = .0022). In the group treated with the fibrin bandages, there was no significant decrease in the mean arterial pressure after arterial laceration. In contrast, there was a decrease of 30 mm Hg in the group treated with gauze dressings alone. There was no animal mortality during the study period.

CONCLUSIONS:

Bandages containing fibrinogen and thrombin significantly reduced the amount of blood loss and allowed mean arterial pressures to be maintained in animals with uncontrolled hemorrhage from femoral artery lacerations. A hemostatic bandage may be an important adjuvant for controlling severe extremity hemorrhage in the prehospital setting.

PMID:
7710344
[Indexed for MEDLINE]

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