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Trends Biochem Sci. 1995 Mar;20(3):109-13.

How specific is the first recognition step of homologous recombination?

Author information

1
Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.

Abstract

The Escherichia coli RecA protein promotes homologous recognition in base triplets via non-Watson-Crick bonds that differ from those formed nonenzymically from DNA consisting of runs of purines or pyrimidines. Base substitutions reveal recognition to be permissive, consistent with a search for homology that achieves speed at the cost of precision.

PMID:
7709428
DOI:
10.1016/s0968-0004(00)88976-8
[Indexed for MEDLINE]

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