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Int Rev Cytol. 1995;157:129-79.

Murine B cell development: commitment and progression from multipotential progenitors to mature B lymphocytes.

Author information

1
Wellesley Hospital Research Institute, Toronto, Ontario, Canada.

Abstract

B lymphocytes, the cellular source of antibody, are critical components of the immune response. They develop from multipotential stem cells, progressively acquiring the traits that allow them to function as mature B lymphocytes. This developmental program is dependent on appropriate interactions with the surrounding environment. These interactions, mediated by cell-cell and cell-matrix interactions, provide the growth and differentiation signals that promote progression along the developmental pathway. This chapter addresses the properties of developing B lineage cells and the nature of the environmental signals that support B lineage progression.

PMID:
7706019
DOI:
10.1016/s0074-7696(08)62158-0
[Indexed for MEDLINE]

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