Format

Send to

Choose Destination
Eur J Immunol. 1995 Mar;25(3):863-5.

CD40 ligand is functionally expressed on human eosinophils.

Author information

1
Glaxo Institute for Molecular Biology, Plan les Ouates/Geneva, Switzerland.

Abstract

CD40 ligand (CD40L), a surface molecule which can be expressed by T cells, mast cells and basophils, has been shown to be involved in the control of B cell proliferation, immunoglobulin class switching as well as in the activation of monocytes and T cells. We demonstrate that CD40L can also be expressed constitutively by eosinophils from an hypereosinophilic patient or, upon activation, by the eosinophilic cell line EOL-3 and normal blood eosinophils. Eosinophils were able to induce, in conjunction with IL-4, CD40L-dependent B cell proliferation in vitro. These results suggest that CD40L could play a role in the inflammatory processes during which eosinophil infiltration and activation are observed.

PMID:
7705419
DOI:
10.1002/eji.1830250335
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center