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Arch Otolaryngol Head Neck Surg. 1995 Apr;121(4):445-8.

Prophylactic antibiotic drops after tympanostomy tube placement.

Author information

1
Department of Surgery, University of Kentucky Medical Center, Lexington, USA.

Abstract

OBJECTIVE:

To evaluate the effectiveness of prophylactic polymyxin B sulfate-neomycin sulfate-hydrocortisone drops in decreasing the incidence of posttympanostomy otorrhea.

DESIGN:

Prospective randomized controlled study.

SETTING:

University referral center.

PATIENTS:

Three hundred patients undergoing tympanostomy tube placement (including those undergoing tonsillectomy, adenoidectomy, or both) were randomized into three groups.

INTERVENTION:

The use of polymyxin B-neomycin-hydrocortisone drops. Patients in group 1 received no antibiotic drops; group 2, a single dose intraoperatively, and group 3, an intraoperative dose followed by a 5-day course.

MAIN OUTCOME MEASURE:

Posttympanostomy otorrhea.

RESULTS:

A statistically significant decrease was observed in the incidence of posttympanostomy otorrhea between the control (16.4%) and treatment groups (group 2, 8.3%; group 3, 8.1%) (P = .011). A single dose of antibiotics was effective when patients' middle ears were dry or had serous effusions. A 5-day course was indicated for those whose ears had mucoid or purulent contents.

CONCLUSIONS:

Antibiotic ear drops are indicated in all patients. A single dose is as effective as a 5-day course, but our data support a longer course in certain subgroups.

PMID:
7702820
[Indexed for MEDLINE]

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