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Eur J Clin Microbiol Infect Dis. 1994 Nov;13(11):994-9.

Animal and cell-culture models for the study of mycobacterial infections and treatment.

Author information

1
Department of Microbiology, Colorado State University, Fort Collins 80523, USA.

Abstract

Emerging problems with the treatment of infections caused by Mycobacterium avium and Mycobacterium tuberculosis require the development of new models, both in vitro and in vivo, in which new chemotherapeutic and immunotherapeutic approaches can be tested. In this brief review, the use of cell culture models, in which drugs can be tested for their capacity to inhibit mycobacterial growth within the infected host macrophage, and new models in vivo in which drugs and/or cytokines can be tested in infected mice are discussed. In this latter case, new emerging mouse models include animals with engineered gene disruptions, in which severely disseminated infections can be produced, thus mimicking events in severely immunocompromised human patients.

PMID:
7698125
DOI:
10.1007/bf02111500
[Indexed for MEDLINE]

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