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Cytogenet Cell Genet. 1995;69(3-4):211-4.

Mapping of the gene for hormone sensitive lipase (LIPE) to chromosome 19q13.1-->q13.2.

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Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore MD, USA.


Free fatty acids are the major source of fuel for mammals, and hormone sensitive lipase (LIPE) plays a critical role in lipid metabolism by mobilizing free fatty acids from stored triglycerides. We have identified and sequenced a partial cDNA for LIPE. Cosmids were identified by hybridization and mapped to 19q13.1-->q13.2 by FISH. Direct sequence analysis of a 1 kb segment of cosmid 26710 identifies a dinucleotide repeat in an intron upstream of exon 8 of human LIPE. This marker was heterozygous 82% of the time with 12 alleles (166-190 bp) detected in 122 chromosomes. The most likely order for this gene is: qter-[D19S178/LIPE]-(3 cM)-D19S47-(1 cM)-D19S190-RYR1-cen.

[Indexed for MEDLINE]

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