Abstract
The Chinese herbal formula suching-huo-hsuei-tang (SHT) was studied to evaluate its efficacy and possible mechanism on adjuvant-induced arthritis (AIA) in rats. SHT was extracted with water, butanol and chloroform into 5 different layers. The top 3 layers of SHT showed a significant suppression of AIA and writhing reaction; the top 2 layers suppressed neutrophil chemotaxis and platelet aggregation. The results suggest that SHT is very promising in the treatment of rheumatoid arthritis (RA) by way of its anti-inflammatory and analgesic action. The possible mechanisms for arthritis are multifactorial.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arthritis, Experimental / drug therapy*
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Capillary Permeability / drug effects
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Chemotaxis, Leukocyte / drug effects*
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Disease Models, Animal
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Drugs, Chinese Herbal / pharmacology
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Drugs, Chinese Herbal / therapeutic use*
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Enzyme-Linked Immunosorbent Assay
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Immunoglobulin G / blood
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Interferons / metabolism
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Male
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Neutrophils / drug effects*
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Platelet Aggregation / drug effects*
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Platelet Aggregation Inhibitors / pharmacology
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Platelet Aggregation Inhibitors / therapeutic use
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Rats
Substances
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Drugs, Chinese Herbal
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Immunoglobulin G
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Platelet Aggregation Inhibitors
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Interferons