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West J Med. 1993 Sep;159(3):312-7.

Maternal serum screening for neural tube defects and fetal chromosome abnormalities.

Author information

1
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104.

Abstract

Second-trimester maternal serum screening is a noninvasive means of identifying pregnant women at an increased risk for various conditions including a fetus with open spina bifida, fetal Down syndrome, trisomy 18, multiple gestation, and adverse pregnancy outcome. Combinations of several different markers are available for screening. These include alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol. In this review, we discuss the benefits and limitations of the screening tests and the suggested protocols for the care of patients.

PMID:
7694429
PMCID:
PMC1011344
[Indexed for MEDLINE]
Free PMC Article

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