Format

Send to

Choose Destination
Trends Neurosci. 1993 Sep;16(9):359-65.

The TINS/TiPS Lecture. The molecular biology of mammalian glutamate receptor channels.

Author information

1
University of Heidelberg, Centre of Molecular Biology (ZMBH), Laboratory of Molecular Neuroendocrinology, Germany.

Abstract

In native brain membranes the principal excitatory neurotransmitter L-glutamate activates cation-conducting channels with distinct biophysical and pharmacological properties. Molecular cloning has revealed the existence of 16 channel subunits that can assemble in homomeric or heteromeric configurations in vitro to form receptor channels with disparate functional properties. This review describes the different channel types obtained by recombinant means and the genetic mechanisms controlling the expression of functionally important channel structures.

PMID:
7694406
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center