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Brain Res Mol Brain Res. 1993 Sep;19(4):323-7.

'Binge' cocaine administration induces a sustained increase of prodynorphin mRNA in rat caudate-putamen.

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Biology of Addictive Diseases Laboratory, Rockefeller University, New York, NY 10021.


Other workers have established that cocaine injections increase the levels of dynorphin peptides in the caudate putamen and substantia nigra of the rat brain. Using a quantitative solution hybridization protection assay for mRNA, we detected a significant increase in the concentration of prodynorphin mRNA in caudate putamen extracts of rats injected with cocaine following a 'binge' administration pattern designed to mimic human cocaine abuse. Increased prodynorphin mRNA was observed at the earliest time-point studied (50 h) and the lowest dose (10 mg/kg/day) of cocaine tested and persisted through the 14 day period studied. No prodynorphin mRNA was detected in the substantia nigra.

[Indexed for MEDLINE]

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