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J Med Chem. 1993 Oct 15;36(21):3197-201.

Synthesis, in vitro binding profile, and autoradiographic analysis of [3H]-cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine, a highly potent and selective nonpeptide substance P receptor antagonist radioligand.

Author information

1
Pfizer Central Research, Department of Medicinal Chemistry, Groton, Connecticut 06340.

Abstract

The synthesis of a highly potent and selective NK1 receptor antagonist radioligand, [3H]-cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine (6a) is described. The in vitro binding pharmacology and autoradiographic distribution of 6a in guinea pig brain following peripheral administration are also reported.

PMID:
7693945
DOI:
10.1021/jm00073a022
[Indexed for MEDLINE]

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