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Nucleic Acids Res. 1993 Sep 11;21(18):4210-7.

hnRNP G: sequence and characterization of a glycosylated RNA-binding protein.

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1
INSERM U-301, Institut de Génétique Moléculaire, Paris, France.

Abstract

The autoantigen p43 is a nuclear protein initially identified with autoantibodies from dogs with a lupus-like syndrome. Here we show that p43 is an RNA-binding protein, and identify it as hnRNP G, a previously described component of heterogeneous nuclear ribonucleoprotein complexes. We demonstrate that p43/hnRNP G is glycosylated, and identify the modification as O-linked N-acetylglucosamine. A full-length cDNA clone for hnRNP G has been isolated and sequenced, and the predicted amino acid sequence for hnRNP G shows that it contains one RNP-consensus RNA binding domain (RBD) at the amino terminus and a carboxyl domain rich in serines, arginines and glycines. The RBD of human hnRNP G shows striking similarities with the RBDs of several plant RNA-binding proteins.

PMID:
7692398
PMCID:
PMC310052
[Indexed for MEDLINE]
Free PMC Article
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