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Trends Genet. 1993 Aug;9(8):285-90.

From white spots to stem cells: the role of the Kit receptor in mammalian development.

Author information

1
Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas 75235-8852.

Abstract

The Kit tyrosine kinase membrane receptor is essential for melanogenesis, gametogenesis and hematopoiesis during embryonic development and postnatal life. This review summarizes the genetic evidence implicating Kit and its ligand, Steel factor, in the control of stem cell proliferation, migration and survival, with emphasis on mutations in the human and mouse genes.

PMID:
7691001
DOI:
10.1016/0168-9525(93)90015-a
[Indexed for MEDLINE]

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