Format

Send to

Choose Destination
J Antibiot (Tokyo). 1993 Jul;46(7):1149-55.

Tautomeric phenomenon of a novel potent immunosuppressant (FK506) in solution. I. Isolation and structure determination of tautomeric compounds.

Author information

1
Analytical Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.

Abstract

Tautomeric phenomenon was observed in the HPLC chromatogram obtained from a novel potent immunosuppressant, FK506, in ethanol solution. Two tautomeric compounds derived from FK506 were isolated and purified by HPLC. Their structures were elucidated by spectral analyses. The mechanisms for this tautomerization were also established based on the results of structure analysis.

PMID:
7689551
DOI:
10.7164/antibiotics.46.1149
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
Loading ...
Support Center