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FEBS Lett. 1993 Aug 23;329(1-2):21-4.

Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties.

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  • 1A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russian Federation.


Caffeic acid phenethyl ester, an active component of propolis extract, inhibits 5-lipoxygenase in the micromolar concentration range. The inhibition is of an uncompetitive type, i.e. the inhibitor binds to the enzyme-substrate complex but not to the free enzyme. Caffeic acid phenethyl ester also exhibits antioxidant properties. At a concentration of 10 microM, it completely blocks production of reactive oxygen species in human neutrophils and the xanthine/xanthine oxidase system.

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