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Pain. 1993 Jun;53(3):353-5.

Opioid hyperexcitability: the application of alternate opioid therapy.

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1
Alberta Cancer Foundation, University of Alberta, Edmonton, Canada.

Abstract

Three cases are reported where patients experienced severe central nervous system adverse effects on high-dose hydromorphone. These effects were rapidly alleviated following a change in therapy to morphine at 20-25% of the usually accepted potency equivalent dose. We recommend caution in using equivalent dose tables when changing opioid therapy in patients receiving high-dose opioid treatment.

PMID:
7688888
[Indexed for MEDLINE]
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