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Curr Opin Immunol. 1993 Jun;5(3):361-7.

Molecules involved in T-cell costimulation.

Author information

1
Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455.

Abstract

Maximal expression of the interleukin-2 gene in T cells depends on biochemical signals in addition to those transduced by the T cell antigen receptor. Recent work indicates that the T-cell specific molecule CD28 transduces a 'costimulatory' signal when it binds its ligand, the B7 molecule, on the surface of an antigen-presenting cell. Results from experiments performed during the past year have raised the exciting possibility that immune responses can be either inhibited or augmented by manipulation of the CD28-B7 interaction.

PMID:
7688514
DOI:
10.1016/0952-7915(93)90054-v
[Indexed for MEDLINE]

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