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Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):6900-3.

Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation.

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1
McArdie Laboratory, University of Wisconsin, Madison 53706.

Abstract

Human immunodeficiency virus variation is extensive and is based on numerous mistakes in reverse transcription. All retrovirus replication requires two strand transfers (growing point jumps) to synthesize the complete provirus. I propose that the numerous mistakes in reverse transcription are the result of this requirement for the two strand transfers needed to form the provirus.

PMID:
7688465
PMCID:
PMC47042
[Indexed for MEDLINE]
Free PMC Article
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