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Mutat Res. 1993 Aug;288(2):277-80.

The scid mutation in mice causes defects in the repair system for both double-strand DNA breaks and DNA cross-links.

Author information

1
Department of Medicine III, Osaka University Medical School, Japan.

Abstract

The sensitivity of scid fibroblasts established from C.B17-scid/scid fetuses to the DNA-damaging agents bleomycin, neocarzinostatin, mechlorethamine, mitomycin C, methyl methanesulfonate, and ultraviolet light, all of which induce different types of DNA damage, was examined. Scid fibroblasts were 2.8-, 3.7-, and 3.0-fold more sensitive to bleomycin, neocarzinostatin, and mechlorethamine, respectively, than wild-type fibroblasts derived from C.B17-+/+ fetuses. These findings indicate that the scid mutation in mice causes defects in repairing both double-strand DNA breaks and DNA cross-links.

PMID:
7688088
DOI:
10.1016/0027-5107(93)90095-w
[Indexed for MEDLINE]

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