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Lancet. 1993 Jul 17;342(8864):147-8.

Photodynamic therapy of oral cancer: photosensitisation with systemic aminolaevulinic acid.

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1
National Medical Laser Centre, University College London Medical School, UK.

Abstract

Photodynamic therapy with intravenous photosensitising drugs has been shown to be effective in the ablation of superficial cancers, but long-lasting photosensitivity is a serious disadvantage. Similar photosensitivity is a feature of certain types of porphyria. We present the first report of tumour necrosis brought about by photodynamic activation of a temporary endogenous porphyrin accumulation, after an oral dose of the haem precursor, 5-aminolaevulinic acid. In 4 patients, quantitative fluorescence microscopy showed that accumulation of the photoactive intermediate protoporphyrin IX peaked after 4-6 h in 4 oral cavity squamous cell carcinomas, returning to background in 24 h. Irradiation with non-thermal red laser light caused tumour necrosis in 3 patients.

PMID:
7687318
[Indexed for MEDLINE]
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