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Immunol Today. 1993 May;14(5):203-8.

Determinant spreading and the dynamics of the autoimmune T-cell repertoire.

Author information

1
Dept of Pathology, Case Western Reserve University, Cleveland, OH 44106.

Abstract

In this article the authors propose a dynamic model of autoimmunity with T-cell recruitment and selection leading to changes in the specificity of the anti-self response during the course of disease. They argue that these changes are due to alterations in self-antigen presentation that lead to the display of previously cryptic self-determinants. Mechanisms that could underlie this differential self-presentation are proposed.

PMID:
7686009
DOI:
10.1016/0167-5699(93)90163-F
[Indexed for MEDLINE]

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