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Pflugers Arch. 1993 Feb;422(5):472-5.

Prolonged exercise reduces Ca2+ release in rat skeletal muscle sarcoplasmic reticulum.

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Department of Exercise and Movement Science, University of Oregon, Eugene 97403.


Prolonged exercise decreased the rate of Ca+ release in sarcoplasmic reticulum (SR) vesicles isolated from rat muscle by 20-30% when release was initiated by 5, 10, and 20 microM AgNO3 [3H]Ryanodine binding was also depressed by 20% in SR vesicles isolated from the exercised animals. In contrast, the maximum amount of Ca2+ release in the presence of ruthenium red, a known inhibitor of the Ca2+ release mechanism, was not affected by prolonged exercise. These results suggest that exercise depressed Ca2+ release from SR by directly modifying the Ca2+ release channel.

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