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Int J Cancer. 1993 Apr 1;53(6):898-901.

Epstein-Barr virus and gastric cancer: data and unanswered questions.

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Institute of Pathologic Anatomy and Histology, University of Siena, Italy.


Sixty-five unselected cases of gastric cancer have been analysed for EBV DNA by polymerase chain reaction, in situ hybridization and immunohistochemistry for CD21 antigen expression. Four cases were found EBV-positive by PCR, while ISH yielded positive results in 3 of these cases, demonstrating EBV in the nuclei of cancerous cells. CD21 antigen was expressed in cancerous cells in all 3 ISH-positive cases. All the EBV-positive cancers of the present series were poorly to moderately differentiated adenocarcinomas with prominent lymphoid infiltration. These results are discussed also on the basis of the literature.

[Indexed for MEDLINE]

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