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Neurosci Lett. 1993 Mar 5;151(1):67-70.

Enzymehistochemical demonstration of nitric oxide synthase in the diencephalon of the rainbow trout (Oncorhynchus mickiss).

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Department of Neuroanatomy, School of Medicine, University of Göttingen, FRG.


Nitric oxide, a free radical, has recently been shown to exert major influences on CNS functions in mammals. It is synthesized by NO-synthase. For the first time, this study reveals this enzyme's existence in the CNS of a teleost fish and describes its distribution in the diencephalon, where the paraventricular organ displays an extraordinarily high activity. The study contributes to an evolutionary perspective of the biological role played by nitric oxide in the vertebrate CNS, and raises questions regarding the significance of this gas in cerebrospinal fluid-contacting neurons.

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