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Am J Obstet Gynecol. 1993 Mar;168(3 Pt 1):787-92.

Identification of patients with persistent trophoblastic disease by means of a normal human chorionic gonadotropin regression curve.

Author information

1
Department of Obstetrics and Gynecology, University Hospital Nijmegen, The Netherlands.

Abstract

OBJECTIVE:

Data from the Dutch Central Registry of Hydatidiform Mole were used to establish a reference human chorionic gonadotropin regression curve after molar pregnancy.

STUDY DESIGN:

A normal serum human chorionic gonadotropin regression corridor was constructed after fitting data from 130 patients with uneventful human chorionic gonadotropin regression after evacuation of a complete hydatidiform mole. Retrospectively, data from 77 patients with persistent trophoblastic disease were analyzed by means of this normal corridor. Measurements were performed with a radioimmunoassay for both native and free human chorionic gonadotropin beta-subunits.

RESULTS:

Human chorionic gonadotropin disappearance curves showed a biphasic decline with median serum half-lives of 1.8 and 12.8 days. Median time until normalization was 74 days (range 28 to 430). With the 95th percentile line, 71 of 77 patients (92%) with persistent trophoblastic disease could be identified. In > 50% of cases this could be achieved within 6 weeks from evacuation.

CONCLUSION:

The normal regression corridor allows identification of patients with persistent trophoblastic disease and an expectant attitude within the limits of the corridor.

PMID:
7681253
DOI:
10.1016/s0002-9378(12)90820-0
[Indexed for MEDLINE]

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