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Curr Opin Immunol. 1993 Feb;5(1):35-44.

MHC molecules as peptide receptors.

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Max-Planck Institute für Biologie, Abteilung Immungenetik, Tübingen, Germany.


The central unit for regulation of the specific immune system is a trimolecular complex made up of the T cell antigen receptor, the MHC molecule, and the MHC ligand. The third component is a peptide derived as a degradation product from a protein. During recent years there has been some progress in understanding the interaction between MHC molecules and their peptide ligands: MHC molecules are peptide receptors of peculiar specificity, being able to accommodate millions of different peptides provided they share some common features.

[Indexed for MEDLINE]

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