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Science. 1993 Jan 15;259(5093):368-70.

Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells.

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Department of Molecular and Cell Biology, University of California, Berkeley 94720.


A variety of tumors are potentially immunogenic but do not stimulate an effective anti-tumor immune response in vivo. Tumors may be capable of delivering antigen-specific signals to T cells, but may not deliver the costimulatory signals necessary for full activation of T cells. Expression of the costimulatory ligand B7 on melanoma cells was found to induce the rejection of a murine melanoma in vivo. This rejection was mediated by CD8+ T cells; CD4+ T cells were not required. These results suggest that B7 expression renders tumor cells capable of effective antigen presentation, leading to their eradication in vivo.

[Indexed for MEDLINE]

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