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Biochem Biophys Res Commun. 1995 Sep 14;214(2):723-9.

On the relationship of the ATP-independent, mitochondrial associated DNA topoisomerase of Saccharomyces cerevisiae to the nuclear topoisomerase I.

Author information

1
Department of Chemistry, Auburn University, AL 36849-5312, USA.

Abstract

A mitochondrial type I-like, ATP-independent, DNA topoisomerase, isolated from highly purified yeast mitochondria, is genetically related to nuclear topoisomerase I. We found that the mitochondrial topoisomerase activity cannot be detected in yeast mitochondrial extracts prepared from strains in which the topoisomerase I gene (TOP1) is disrupted. Thus, the topoisomerase activity associated with mitochondria is dependent upon the expression of the nuclear topoisomerase I gene.

PMID:
7677787
DOI:
10.1006/bbrc.1995.2345
[Indexed for MEDLINE]

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