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Biochem Biophys Res Commun. 1995 Sep 14;214(2):475-81.

Mutant IGF-I receptors as dominant negatives for growth and transformation.

Author information

1
Jefferson Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Abstract

The insulin-like growth factor I receptor (IGF-IR) plays a crucial role in cell growth, transformation and protection from apoptosis. We have transfected several mutant IGF-IRs into C6 rat glioblastoma cells, in order to determine whether they can act as dominant negatives. We find that some of them can act as dominant negatives in growth assays (monolayer or soft agar), but that none of those examined can induce apoptosis in C6 cells.

PMID:
7677754
DOI:
10.1006/bbrc.1995.2311
[Indexed for MEDLINE]
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