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Clin Perinatol. 1995 Jun;22(2):481-517.

Hypoxic-ischemic encephalopathy. Therapeutic approaches against microvascular injury, and role of neutrophils, PAF, and free radicals.

Author information

1
Department of Pediatrics, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, USA.

Abstract

The asphyxiated newborn undergoes progressive brain damage even after resuscitation. This article reviews the microvascular events that contribute to evolving brain injury. The role of neutrophils, platelet-activating factor (PAF), and free radicals is stressed as pivotal mechanisms of injury and opportunities for therapeutic intervention.

PMID:
7671548
[Indexed for MEDLINE]

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