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Cell. 1995 Sep 8;82(5):823-9.

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

Author information

1
Department of Biology, University of North Carolina, Chapel Hill 27599-3280, USA.

Abstract

Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G1-3T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amino acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is the human ataxia telangiectasia gene.

PMID:
7671310
DOI:
10.1016/0092-8674(95)90479-4
[Indexed for MEDLINE]
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