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Biochem Biophys Res Commun. 1995 Sep 5;214(1):195-9.

Characterization of the genomic structure and the promoter region of the human intestinal trefoil factor.

Author information

1
Department of Human Genetics, University of Saarland, Homburg, Germany.

Abstract

Trefoil proteins form a specific group of stable secretory polypeptides. They are expressed in a lot of human cancers and inflammatory processes of the gastrointestinal tract. Recently a new human trefoil protein, ITF/hP1.B was isolated. This gene is expressed mainly in globet cells of intestinum and colon. The genomic structure of the murine and rat homologues genes were described previously and a high nucleotide sequence conservation (78-95%) was found in the coding as well as the regulatory regions. We have isolated the human genomic ITF-gene region from a P1 library and a detailed analysis yielded in a similar gene structure with a three basepair displacement of the second exon intron boundary. The promoter region of the human gene interestingly is markedly different from rat and mouse.

PMID:
7669039
DOI:
10.1006/bbrc.1995.2274
[Indexed for MEDLINE]

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