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Trends Biochem Sci. 1995 Aug;20(8):303-7.

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.

Author information

1
Ui Laboratory, Institute of Chemical and Physical Research, Wako-shi, Japan.

Abstract

Wortmannin is a fungal metabolite that so far has been shown to act as a selective inhibitor of phosphoinositide 3-kinase. It can therefore be used to investigate the convergence between two major cellular signalling systems: those involving G-protein-coupled receptors and those involving receptor tyrosine kinases. Importantly, wortmannin can enter intact cells, making whole-cell studies of the above signalling pathways possible.

PMID:
7667888
[Indexed for MEDLINE]

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