Send to

Choose Destination
Trends Biochem Sci. 1995 Aug;20(8):303-7.

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.

Author information

Ui Laboratory, Institute of Chemical and Physical Research, Wako-shi, Japan.


Wortmannin is a fungal metabolite that so far has been shown to act as a selective inhibitor of phosphoinositide 3-kinase. It can therefore be used to investigate the convergence between two major cellular signalling systems: those involving G-protein-coupled receptors and those involving receptor tyrosine kinases. Importantly, wortmannin can enter intact cells, making whole-cell studies of the above signalling pathways possible.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center